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Prosthetics and 'Wearables' Research News

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In a new study of patients with Retinitis Pigmentosa, the Keck School of Medicine of USC researchers have found that adapted augmented reality (AR) glasses can improve patients’ mobility by 50% and grasp performance by 70%. Utilizing a different approach by employing assistive technology to enhance natural senses, the team adapted AR glasses that project bright colors onto patients’ retinas, corresponding to nearby obstacles.

What this means for Usher syndrome: we can improve the quality of life for patients with low vision due to retinitis pigmentosa through the use of augmented reality technology.

Scientists from Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland and Scuola Superiore Sant’ Anna in Italy are developing a technology, OpticSELINE, for the blind that stimulates the optic nerve. The idea is to produce phosphenes, the sensation of seeing light in the form of seeing white patterns, without seeing light directly. Unfortunately, only a few hundred patients qualify for the current retinal implants on the market for clinical reasons. The intraneural electrode is a potential solution to this exclusion, since the optic nerve and the pathway to the brain are often intact. Intraneural electrodes contain an array of 12 electrodes and are more stable and less likely to move around once they are implanted. To understand the effectiveness of the electrodes, scientists delivered electric current to the optic nerve through OpticSELINE and measured the brain’s activity . The stimulation showed each electrode induces a special pattern of cortical activation, suggesting that intraneural stimulation of the optic nerve is selective and informative.

What this means for Usher syndrome: newer technologies such as the OpticSELINE are being developed as potential solutions to help the blind see. It might take some time and several clinical trials to fine-tune those stimulated cortical patterns but as they are now those visual signals generated by the OpticSELINE will be able to provide visual aid in the near future.

Scientists from Okayama University have developed a film coupled with photoelectric dye that generates electric signals in response to light. When the device was placed on an instrument that measures electric potential, the film generated waves of electric signals after being exposed to a flashing light. Researchers have highlighted that the device may function as a “novel type of retinal prosthesis.”

What this means for Usher syndrome: This device might be developed into an implant treatment for vision loss in Usher syndrome.

When a person becomes blind their brain’s visual cortex is typically undamaged, but it is not receiving information from the eyes. Six blind people have now had their vision partially restored thanks to Orion, a new device that feeds images from a camera directly into the brain. The Orion device has two main parts: a brain implant and a pair of glasses. The implant consists of sixty electrodes that receive information from a camera mounted on the glasses. Together, they deliver visual information to the brain; thus, bypassing the eye.

What this means for Usher syndrome: This system might provide vision in Usher syndrome patients who are completely blind.

2Ctech Inc, a privately-held development stage company focused on the application of nanoparticle technologies for the treatment of retinal diseases, announced its first-known clinical program to demonstrate the effectiveness and safety of Quantum Dots (QDs) to achieve photovoltaic stimulation of the neural retina for preservation or enhancement of vision in patients with retinal degenerative diseases. QDs are semiconductor crystalline structures that absorb light and generate a dipole electrical field; thus, stimulating the neuronal retina cells. These particles are similar to solar cells, which produce energy in response to light. In the layers of the retina, the particle emissions are intended to result in direct stimulation of the neural retina, “creating action potentials that trigger the normal neural pathways to the brain.

What this means for Usher syndrome: This new technology holds promise to provide a means to restore lost vision in Usher syndrome patients.

In August, it will be a year since the first commercial IRIS®II retinal chip implantation in Europe took place; it has allowed a blind patient to perceive light stimuli and use it to locate objects, meaning that she can be more independent. This work has made it possible to integrate artificial vision technology, which includes an electrical retinal stimulator with over 150 electrodes, glasses with a bio-inspired mini-camera and a pocket processor into this patient’s day-to-day life. For the patient, blind from a result of retinitis pigmentosa, the retinal chip is another way of supporting her in her daily life, together with her guide dog and the use of a cane.

What this means for Usher syndrome: There are possible technologies available to help the blind live and navigate independently.

David Rand, Marie Jakešová, Gur Lubin, Ieva Vėbraitė, Moshe David-Pur, Vedran Đerek, Tobias Cramer, Niyazi Serdar Sariciftci, Yael Hanein, Eric Daniel Głowacki

A simple retinal prosthesis is being developed in collaboration between Tel Aviv University in Israel and Linköping University in Sweden. Fabricated using cheap and widely-available organic pigments used in printing inks and cosmetics, it consists of tiny pixels like a digital camera sensor on a nanometric scale. Researchers hope that it can restore sight to blind people.

An Ottawa-based company, iBionics, is working to improve the effectiveness of vision-restoring technology by developing a bionic retina, the Diamond Eye implant. iBionics is targeting for full approval and commercial availability by 2024.

One of these recent discoveries doesn't replace an entire eye, but supplants a major component of vision. It holds some promise for millions of people who could otherwise go blind. In a first, scientists in China have created artificial photoreceptors to help blind mice see.

A retinal implant allowed a 69 year old woman with macular degeneration to see more than double the usual number of letters on the vision chart. Luxturna, the gene therapy was approved by the FDA in 2017, corrects a mutation found in Leber congential amaurosis (LCA).

Three blind mice could be a thing of the past. Scientists have restored the sight of blind mice by implanting tiny gold prosthetic photoreceptors into their eyes. So far, this incredible technique has only been carried out on mice. However, the work holds some hope for people with degenerative eye diseases such as retinitis pigmentosa or macular degeneration.

Pixium Vision, a company developing innovative bionic vision systems to enable patients who have lost their sight to lead more independent lives, announces today the world’s first successful human implantation and activation of PRIMA, its new generation miniaturized wireless photovoltaic sub-retinal implant, in a patient with severe vision loss from atrophic dry Age-related Macular Degeneration (AMD).

Approved by the U.S. Food and Drug Administration in June, Cochlear’s Nucleus 7 Sound Processor can now stream sound directly from a compatible iPhone, iPad or iPod touch to the sound processor.

Scientists have developed a retinal implant that can restore lost vision in rats, and are planning to trial the procedure in humans later this year. The implant, which converts light into an electrical signal that stimulates retinal neurons, could give hope to millions who experience retinal degeneration – including retinitis pigmentosa – in which photoreceptor cells in the eye begin to break down, leading to blindness.

The prestigious Institute of Ocular Microsurgery in Barcelona implanted the first patient in Spain with IRIS® II, a bionic vision system equipped with a bio-inspired camera and a 150-electrode epi-retinal implant that is designed to be explantable.

Not just Star Trek fiction, a new visor from eSight is a lightweight, high-contrast vision system for legally blind people.

The artificial retina is the first device of its kind to move from the laboratory to the clinic, after a trial of 30 patients has shown that it can safely restore some vision to people who have lost their sight to a genetic disease.

This article describes and compares two retinal implants, one being developed in Israel to the one in clinical trials in the U.S. by Second Sight. While they are both implants, they are also very different. Users of the Israeli one would wear just a special pair of glasses, whereas the Second Sight one includes glasses, a camera, and a processor. In addition, surgery for the Israeli one takes much less time and is less invasive. The Israeli inventors also promise much better vision. It is expected to begin clinical trials in 2013.

Researchers have developed an implant that clears out the scar tissue of diseased retinas and seeds new ones. This quickly evolving procedure holds hope for millions of persons with retinitis pigmentosa (RP) and age-related macular degeneration (ARMD).

ScienceDaily — Researchers trying to restore vision damaged by disease have found promise in a tiny implant that sows seeds of new cells in the eye.

Less than a month ago, at the 2009 International Electron Devices Meeting (IEDM), researchers from Stanford University presented their solution for a retinal implant that has the potential to restore vision in those who lose sight due to age-related macular degeneration (AMD), retinitis pigmentosa (RP), and certain other retinal disorders. The implant is composed of solar cells embedded in a bed of flexible silicon electrodes that transfer visual images to the brain.

New York Times article outlining a number of experimental treatments being tested to help restore vision. An intensive three-year research project involving electrodes surgically implanted in the eye, a camera on the bridge of the nose and a video processor strapped to the waist is part of a burst of recent research.

Led by electrical engineering professor John Wyatt, team develops retinal implant that could help restore useful level of vision to certain groups of blind people. Inspired by the success of cochlear implants that can restore hearing to some deaf people, researchers at MIT are working on a retinal implant that could one day help blind people regain a useful level of vision.

Report on efforts of a team in Germany to develop an electronic retinal prosthesis.

Very little research-based information exists about the benefits and challenges of cochlear implants for children who are deaf or hard of hearing, who also have a vision impairment. A new study aims to remedy that. This multi-year project will address a number of objectives to begin to provide a research base for more informed decision-making by families and service providers, in relation to cochlear implants for children who are deaf-blind.