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Little is known about the effect of Usher Syndrome on carriers. We are interested in acquiring more data on older Usher carriers in order to determine if there are any effects. Some possible impacts are: Carriers of Usher Type I
When only one Usher Type I gene is knocked out, half the normal amount of it’s protein is produced. It is believed that this is sufficient for normal vision and hearing so no clinical symptoms result. Certainly, there has been nothing obvious happening to people who are carriers for any of the Usher disorders. However, there are theoretical reasons to think that there may be very mild hearing and vision problems that occur with older adults but this has never been studied.
Carriers of Usher Type II When only one USH2A gene is knocked out, half the normal amount of usherin is produced. Scientists believe that this is sufficient for normal vision and hearing, therefore no clinical symptoms result. There is nothing obvious happening to people who are carriers for Usher type 2a or 2c. However, there are theoretical reasons to think that there may be very mild hearing and vision problems that occur with older adults, but this has never been studied. It may be that these genes are partly responsible for some of the hearing vision losses that all of us have as we grow older. The story for USH2C is exactly the same.
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